Allergy 4 All

Peanut Patch for Allergy Sufferers

A promising peanut allergy treatment tested by Seattle area doctors entered Phase III trials at the end of 2015.

 

In April 2015, the Viaskin Peanut patch made by French company DBV Technologies was awarded a breakthrough therapy designation by the U.S. Food and Drug Administration (FDA). The designation is intended to accelerate the development and review of treatments of serious conditions. It came after a Phase IIb multicenter clinical trial showed the patch increased the amount of peanut required to trigger an allergic reaction by at least tenfold.

 

The Viaskin Peanut patch administers peanut protein directly into the skin, where it activates an immune response without releasing antigens into the blood. Langerhan cells then transport the peanut protein into the lymph nodes where immune activity takes place. The intact proteins never enter the bloodstream, thereby reducing the chance of allergic reaction.

 

Dr. Stephen Tilles, a physician partner at Northwest Asthma & Allergy Center and executive director of the ASTHMA, Inc. Clinical Research Center, oversaw the study in nine Seattle-area participants. He works with the Seattle Food and Allergy Consortium (SeaFAC), which is dedicated to developing new allergy therapies.

 

Read the full Article here on Institute of Translational Health Sciences

Should babies be given solids earlier to prevent food allergies?

babyeatingIs this one of the worst wrong turns in the history of parenting advice? Telling people to delay the age they start their babies on solid food might be contributing to the rise in food allergies.

Babies used to be given their first solids when they were around 4 months old. Many start showing an interest in the food their family is eating around this time, as well as developing a larger appetite. But since the World Health Organization published a report about a decade ago saying that babies should be exclusively breastfed until 6 months, countries like the UK and US have recommended parents hold off until then.

Read more: Should babies be given solids earlier to prevent food allergies?

Oral Allergy Syndrome (OAS)

sneezeIf you suffer from allergic rhinitis (hay fever), your mouth or throat may become itchy after eating an apple or celery.

This reaction occurs because the proteins found in some fruits and vegetables are very similar to those found in pollen. These proteins can confuse the immune system and cause an allergic reaction or make existing symptoms worse.

Cross-reactivity happens when the immune system thinks one protein is closely related to another. In the case of allergic rhinitis and foods, the result is called oral allergy syndrome (OAS).

The most frequent reaction involves itchiness or swelling of the mouth, face, lip, tongue and throat. Symptoms usually appear immediately after eating raw fruits or vegetables, although the reaction can occur more than an hour later.

Rarely, OAS can cause severe throat swelling or even a systemic reaction, called anaphylaxis (an-a-fi-LAK-sis), in a person who is highly allergic.

OAS can occur at anytime of the year. Although there is no definitive test for the syndrome, affected individuals often have a positive allergy skin test or blood test for specific pollen, along with a history of symptoms after ingestion of the suspected foods.

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Interim Guidance on Early Peanut Introduction and Prevention of Peanut Allergy

PeanutsMILWAUKEE, WI – While an update to the National Institute of Allergy and Infectious Diseases (NIAID) food allergy guidelines is due to begin this summer, a "Consensus Communication on Early Peanut Introduction and the Prevention of Peanut Allergy in High-Risk Infants" has been published today by The Journal of Allergy and Clinical Immunology, an official journal of the American Academy of Allergy, Asthma & Immunology (AAAAI).

Why is this consensus communication important?
The results of the Learning Early About Peanut (LEAP) study provided new evidence to support early, rather than delayed, peanut introduction during the period complementary foods are first given to infants. Specifically, the LEAP study demonstrated a successful 11 to 25% absolute reduction in the risk of developing peanut allergy in high-risk infants (and a relative risk reduction of up to 80%) if peanut was introduced between 4 and 11 months. It is important to note that children with lesser risk factors for peanut allergy were excluded from the LEAP study, so there is no prospective, randomized data that speaks to the benefit or risk of early peanut introduction in the general to low-risk populations.

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